Topical Anti-Inflammatory and Pain
Reliever
Ketoprofen (Orudis) and Piroxicam
(Feldene) are anti-inflammatory
and analgesic drugs which physicians have been prescribing to be
compounded for topical applications.
Arthritis Specialists, Orthopaedic Surgeons and Sports
Medicine Specialists have also prescribed these to be
used in combination with ultrasound.
A 1992 study on the treatment of
gonarthroses (inflammation of the knee joint), the application of
Piroxicam gel (even at a low level of 5mg/gm) resulted in more than
90% improvement of all evaluated criteria, including pain,
mobility and required assistance during change of position (sitting,
standing up, and climbing stairs). The gel was applied to the
joint area 3 times daily for 2 weeks. Tolerance level was
97.5%. The conclusion to this study states that Piroxicam gel
is an important asset to local treatment in rheumatology and will be
a valuable asset to orthopedic surgery and sports
medicine.1
With a prescription from a physician, we
at Saint John's Medical Plaza Pharmacy can prepare Ketoprofen,
Ketoprofen with Piroxicam for additional anti-inflammatory effects
and Ketoprofen with Lidocaine for anti-inflammatory and numbing
effects.
Ketoprofen and Piroxicam are both
non-steroidal anti-inflammatory drugs (NSAIDs). Ketoprofen is
structurally related to Fenoprofen, Ibuprofen and Naproxen.2 Piroxicam is structurally unrelated to other
NSAIDs.3
Per your physician's
diagnosis and prescription, Gabapentin (Neurontin), Ketamine
(Ketalar), Misoprostal (Cytotec), Capsaicin, Amitriptyline
(Elavil), Baclofen and many other active drugs could be added
to the above for various types of pain
relief.
BASE
USED
These active drugs are prepared in
a Pluronic Lecithin Organogel (PLO gel) vehicle. PLO is an
antipyretic gel, which becomes more viscous as it warms up by body
heat.
Notes:
1 Vachtenheim J. Feldene in local therapy of
deforming gonarthroses. Vnitrni Lekarstvi (Czech). 1992;
38(2):155-159.
2 Allen, Loyd V Jr. Ketoprofen
gel. The Complete U.S. Pharmacist Collection: Allen's Compounded
Formulations; American Pharmaceutical Association, Washington, DC.
2003; pp 90-91.
3 Allen, Loyd V Jr. Piroxicam topical gel. The
Complete U.S. Pharmacist Collection: Allen's Compounded
Formulations; American Pharmaceutical Association, Washington, DC.
2003; pp 94-95.
4 Chi SC, Jun HW. Anti-inflammatory activities of ketoprofen
gel on carrageenan-induced paw edema in rats. J Pharm Sci. 1990;
79(11):974-977.
5 Chi
SC, Jun HW, Release rates of ketoprofen from
poloxamer gels in a membraneless diffusion cell. J Pharm Sci.
1991;
80(3):280-283.
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